Month: September 2015

Colorectal Cancer Genome

[PMID: 26416732] [Nature]

The genomic landscape of response to EGFR blockade in colorectal cancer

“complete exome sequence and copy number analyses of 129 patient-derived tumour grafts and targeted genomic analyses of 55 patient tumours, all of which were KRAS wild-type.”


Points of Significance

[] [Nature Methods]

Association, correlation and causation

Correlation implies association, but not causation. Conversely, causation implies association, but not correlation.


Pancreatic Cancer Subtypes

[PMID: 26343385] [Nature Genetics]

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

“Using bioinformatics approaches to decipher gene expression signatures derived specifically from either tumor cells or nonmalignant stromal cells that predict patient outcome”


Optimization of Cancer Genome Analysis

[] [Cell Systems]

Optimizing Cancer Genome Sequencing and Analysis

Washington University St. Louis  group. “Current sequencing strategies are inadequate given the complexity of most tumors. Current analysis strategies perform poorly, missing rare clinically relevant variants. A comprehensive strategy allows for a more definitive model of tumor clonal architecture.”


21-Gene Assay

[PMID: 26412349] [New England Journal of Medicine]

Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

TAILORx trial on Oncotype DX. “For those seeking confirmation that this assay can identify a cohort of patients who should be spared chemotherapy, this result is both reassuring and frustrating.”


Somatic Mutations

[PMID: 26404825] [Science]

Somatic mutation in cancer and normal cells 

Review from Peter Campbell.