Breast Cancer Kinome Variants

[PMID: 26420498] [Scientific Reports]

Characterization of DNA variants in the human kinome in breast cancer

SOLiD targeted sequencing in 518 kinases and 68 additional cancer related genes in 73 primary breast cancers and 19 metastatic lesions. Validation in TCGA. “We did not exclude known, germ line, single nucleotide polymorphisms (SNP) from our analysis because we hypothesized that functional interactions may exist between germ line and somatic events in the kinome.”

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