Targeted NGS in TNBC

[PMID: 26433948] [Breast Cancer Research]

Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

1,977 genes targeted NGS in 56 pre-treatment TNBC tumors and matched normal DNA. Few recurrent mutations were found, but PIK3CA mutations were exclusively observed in patients proficient for BRCA1.

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