TCGA Lobular Breast Cancer

[PMID:26451490] [Cell]

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

“817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features.” “Conversely, GATA3 mutations and high expression characterized luminal A IDC, suggesting differential modulation of ER activity in ILC and IDC.” “Mixed IDC/ILC cases were molecularly classified as ILC-like and IDC-like revealing no true hybrid features.”

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