Mini-driver Model

[PMID: 26456849] [Nature Reviews Cancer]

The mini-driver model of polygenic cancer evolution

“many mutations found in cancer might not be major drivers or ‘passenger’ mutations, but instead might have relatively weak tumour-promoting effects. Our aim is to highlight the existence of these mutations (termed ‘mini drivers’ herein), as multiple mini-driver mutations might substitute for a major-driver change, especially in the presence of genomic instability or high mutagen exposure.”

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