Genotype 2 Outcome

[PMID:26474971] [Genome Medicine]

A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients

“Main steps of the algorithm termed G-2-O (genotype to outcome) involve splitting TCGA samples into two cohorts using mutation status of the gene(s), then identifying differentially expressed genes between these cohorts using ROC analysis, and rendering a survival analysis using an independent dataset established using gene chip data.”


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