Tumor Xenograft HTS

[PMID:26479923] [Nature Medicine]

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

“We established ~1,000 patient-derived tumor xenograft models (PDXs) with a diverse set of driver mutations. With these PDXs, we performed in vivo compound screens using a 1 × 1 × 1 experimental design (PDX clinical trial or PCT) to assess the population responses to 62 treatments across six indications.”

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