Breast Cancer ESR1 Mutations

[PMID: 26500237] [Clinical Cancer Research]

Sensitive detection of mono- and polyclonal ESR1 mutations in primary tumors, metastatic lesions and cell free DNA of breast cancer patients

“ESR1 mutations were detected at very low allele frequencies in some primary breast cancers, and at high allele frequency in metastases and cfDNA, suggesting that in some tumors rare ESR1 mutant clones are enriched by endocrine therapy.”

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