Multifocal Clonal Evolution

[PMID:26530965] [Nature Communications]

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

“We characterize genomic architecture and infer clonal evolution in eight tumour biopsies and nine plasma samples collected over 1,193 days of clinical follow-up using exome and targeted amplicon sequencing. Mutation levels in the plasma samples reflect the clonal hierarchy inferred from sequencing of tumour biopsies. Serial changes in circulating levels of sub-clonal private mutations correlate with different treatment responses between metastatic sites.”


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