[PMID:26525104] [Cancer Cell]

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

“Tumors “educate” platelets (TEPs) by altering the platelet RNA profile; TEPs provide a RNA biosource for pan-cancer, multiclass, and companion diagnostics; TEP-based liquid biopsies may guide clinical diagnostics and therapy selection; A total of 100–500 pg of total platelet RNA is sufficient for TEP-based diagnostics” “this diagnostic platform — based on sequencing RNA obtained from blood platelets and self-learning algorithms — can discriminate patients with cancer from healthy controls, predict the localization of the primary tumour and provide information on the molecular tumour phenotype.”


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