INTEGRATE

[PMID:26556708] [Genome Research]

INTEGRATE: Gene fusion discovery using whole genome and transcriptome data

“Currently, there are many computational tools that predict structural variations (SV) and gene fusions using whole genome (WGS) and transcriptome sequencing (RNA-seq) data separately. However, as both WGS and RNA-seq have their limitations when used independently we hypothesize that the orthogonal validation from integrating WGS and RNA-seq could generate a sensitive and specific approach for detecting high confidence gene fusion predictions.” “a gene fusion discovery tool, INTEGRATE, that leverages both RNA-seq and WGS data to reconstruct gene fusion junctions and genomic breakpoints by split-read mapping.”

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