Three Strikes

[PMID:26559571] [New England Journal of Medicine]

The Genetic Evolution of Melanoma from Precursor Lesions

“293 cancer-relevant genes in 150 areas of 37 primary melanomas and their adjacent precursor lesions” “distinct evolutionary trajectories for different melanoma subtypes” See also the commentary by Bert Vogelstein: The Path to Cancer — Three Strikes and You’re Out [PMID:26559569].

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