Pediatric Cancer Germline Mutations

[PMID:26580448] [New England Journal of Medicine]

Germline Mutations in Predisposition Genes in Pediatric Cancer

“analyze the genomes of 1120 children and adolescents with cancer. We describe the prevalence and spectrum of germline variants among 565 cancer-associated genes, with an emphasis on the analysis of 60 genes that have been associated with autosomal dominant cancer-predisposition syndromes.” Work from St. Jude’ PCGP.

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