Single-CTC WGS

[PMID:26575023] [Oncotarget]

A comparison of isolated circulating tumor cells and tissue biopsies using whole-genome sequencing in prostate cancer

“Using high-quality WGS on single-CTCs, we identified the shared genomic alterations between CTCs and tumor tissues.” “we observed a trend: the number of shared mutations discovered in the CTCs increased as we sequenced more CTCs. This would imply that at any given time point, multiple CTCs would be needed to better approximate the genomic content of the underlying disease (i.e. addressing spatial heterogeneity). “

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