Germline Findings in Tumor-Only Sequencing

[PMID:26590952] [Journal of National Cancer Institute]

Germline Findings in Tumor-Only Sequencing: Points to Consider for Clinicians and Laboratories

“Analysis of the cancer genome is most informative when paired with germline genomic DNA to delineate inherited and somatic variants. Although tumor-only analysis remains the most common methodology for numerous reasons, it holds the potential to identify clinically significant germline variants.”

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