Human de novo Germline Mutations

[PMID:26656846] [Nature Genetics]

Timing, rates and spectra of human germline mutation

“genome-wide mutation rates and spectra in multi-sibling families”, “consistency in germline mutation spectra between the sexes and at different paternal ages. In parental germ line, 3.8% of mutations were mosaic, resulting in 1.3% of mutations being shared by siblings.” Work from Michael Stratton, Matthew Hurles & UK10K.

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