Tissues vs. Species

[PMID:26694591] [Genome Biology]

Meta-analysis of RNA-seq expression data across species, tissues and studies

Analyses from mouse ENCODE [PMID:25409824] and Michael Synder’s group [PMID:25413365] suggested that gene expression data from human and mouse tend to cluster more by species rather than by tissue, whereas Yoav Gilad disagreed [F1000Research]. This meta-analysis of RNA-Seq work supported the latter, “samples clustered exclusively by tissue rather than by species or study, supporting conservation of organ physiology in mammals”.

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