cfDNA Tissues-of-Origin

[PMID:26771485] [Cell]

Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

“Sequencing cell-free DNA yields a genome-wide map of in vivo nucleosome occupancy. Short cell-free DNA fragments directly footprint transcription factor occupancy. In healthy persons, these epigenetic footprints match hematopoietic lineages. Additional contributions are detected in cancer, often aligning with the cancer type.” Work from Jay Shendure.

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