Neutral Tumor Evolution

[PMID:26780609] [Nature Genetics]

Identification of neutral tumor evolution across cancer types

“the neutral power law fits with high precision 323 of 904 cancers from 14 types and from different cohorts. In malignancies identified as evolving neutrally, all clonal selection seemingly occurred before the onset of cancer growth and not in later-arising subclones, resulting in numerous passenger mutations that are responsible for intratumoral heterogeneity.”

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