Large Somatic CNV

[PMID:26772196] [Genome Research]

Assessment of megabase-scale somatic copy number variation using single cell sequencing

“it is unknown whether organismal function requires that every cell maintain a balanced genome. It is possible that large somatic CNVs are tolerated or even positively selected.””We discover large CNVs in 8-9% of cells across tissues and identify two recurrent CNVs. We conclude that large CNVs can be tolerated in subpopulations of cells and that particular CNVs are relatively prevalent within and across individuals.”


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