ICGC Breast Cancer Genomes

[PMID:27135926] [Nature]

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

“whole-genome sequences of 560 breast cancers” “Mutational signature analysis was extended to genome rearrangements”

See also:

[PMID:27136393] [Nature Communications]

The topography of mutational processes in breast cancer genomes

“each of 12 base substitution, 2 insertion/deletion (indel) and 6 rearrangement mutational signatures present in breast tissue, exhibit distinct relationships with genomic features relating to transcription, DNA replication and chromatin organization”

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