ICGC Breast Cancer Genomes

[PMID:27135926] [Nature]

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

“whole-genome sequences of 560 breast cancers” “Mutational signature analysis was extended to genome rearrangements”

See also:

[PMID:27136393] [Nature Communications]

The topography of mutational processes in breast cancer genomes

“each of 12 base substitution, 2 insertion/deletion (indel) and 6 rearrangement mutational signatures present in breast tissue, exhibit distinct relationships with genomic features relating to transcription, DNA replication and chromatin organization”


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s