Cancer Genome Three-Dimensional Interactions

[PMID:27053337] [Genome Research]

Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations

“Here, we performed Hi-C chromosome conformation capture sequencing to investigate how three-dimensional chromatin organization is disrupted in the context of copy-number variation, long-range epigenetic remodeling, and atypical gene expression programs in prostate cancer. “

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