[PMID:27250555] [Genome Biology]

Vcfanno: fast, flexible annotation of genetic variants

“Here we describe vcfanno, which flexibly extracts and summarizes attributes from multiple annotation files and integrates the annotations within the INFO column of the original VCF file. By leveraging a parallel “chromosome sweeping” algorithm, we demonstrate substantial performance gains by annotating ~85,000 variants per second with 50 attributes from 17 commonly used genome annotation resources.” Vcfanno is written in Go. Aaron Quinlan’s work.


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