Integrative Genomic Personalized Cancer Therapy

[PMID:27245685] [Genome Medicine]

Development and clinical application of an integrative genomic approach to personalized cancer therapy

“We carried out whole exome sequencing (WES) and single-nucleotide polymorphism (SNP) microarray genotyping on DNA from tumor and patient-matched normal specimens, as well as RNA sequencing (RNA-Seq) on available frozen specimens, to identify somatic (tumor-specific) mutations, copy number alterations (CNAs), gene expression changes, gene fusions, and also germline variants.” Work from Rong Chen.

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