BIC-seq2

[PMID:27260798] [Nucleic Acids Research]

Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants

“estimation based on read coverage along the genome suffers from bias due to GC content and other factors. Here, we develop an algorithm called BIC-seq2 that combines normalization of the data at the nucleotide level and Bayesian information criterion-based segmentation to detect both somatic and germline CNVs accurately. Analysis of simulation data showed that this method outperforms existing methods.”

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