[PMID:27333808] [Genome Biology]

MUFFINN: cancer gene discovery via network analysis of somatic mutation data

“a method for prioritizing cancer genes accounting not only for mutations in individual genes but also in their neighbors in functional networks” “This pathway-centric method shows high sensitivity compared with gene-centric analyses of mutation data.” “is highly predictive for known cancer genes, particularly for genes with low mutation occurrence among cancer patients, with the identification of drivers amongst these genes having substantially higher sensitivity than conventional methods based on gene-centric analysis of mutation data. MUFFINN works effectively with both pan-cancer and individual cancer type samples.”


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