HER2+ Breast Cancer WGS

[PMID: 27406316] [Nature Communications]

A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers

“an in-depth genomic characterization of 64 HER2-positive breast tumour genomes that exhibit four subgroups, based on the expression data, with distinctive genomic features in terms of somatic mutations, copy-number changes or structural variations. The results suggest that, despite being clinically defined by a specific gene amplification, HER2-positive tumours melt into the whole luminal–basal breast cancer spectrum rather than standing apart.”

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