Cancer Genes Through WES

[PMID: 27417679] [Nature Communications]

Challenges in identifying cancer genes by analysis of exome sequencing data

“While some cancer genes are identified by analysis of recurrence, spatial clustering or predicted impact of somatic mutations, many remain undetected due to lack of power to discriminate driver mutations from the background mutational load (13–60% recall of cancer genes impacted by somatic single-nucleotide variants, depending on the method). Cancer genes not detected by mutation recurrence also tend to be missed by all types of exome analysis.”

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