MSI in Cancers

[PMID:27694933] [Nature Medicine]

Classification and characterization of microsatellite instability across 18 cancer types

“we examined 5,930 cancer exomes from 18 cancer types at more than 200,000 microsatellite loci and constructed a genomic classifier for MSI. We identified MSI-positive tumors in 14 of the 18 cancer types.” “We also observed a correlation between survival outcomes and the overall burden of unstable microsatellites, suggesting that MSI may be a continuous, rather than discrete, phenotype that is informative across cancer types.” Work from Colin Pritchard and Jay Shendure.

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