Prediction of Cancer Noncoding Mutations

[PMID:27723759] [Nature Genetics]

Chromatin structure–based prediction of recurrent noncoding mutations in cancer

“Here we identified a set of mutations arising in individual samples and altering different cis-regulatory elements that converge on a common gene via chromatin interactions. The mutations and genes identified in this fashion showed strong relevance to cancer, in contrast to noncoding mutations with site-specific recurrence only.”

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