Mutational Profiling in POETIC Multiple Biopsies

[PMID:27827358] [Nature Communications]

Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation

“We conclude that multiple biopsies are essential for confident mutational profiling of ER+ breast cancer and TP53 mutations are associated with resistance to oestrogen deprivation therapy.” “Single-nucleotide variants were detected using the union of three callers”, union for SNVs — I vote for intersection, VarScan has too many calls… “InDels were detected using the union of four callers”, again, union here.

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