[PMID:27869826] [Nature Genetics]

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking

“a computational framework termed cis expression structural alteration mapping (CESAM), which uses statistical concepts from expression quantitative trait locus mapping to integrate SCNAs, expression and chromatin interaction domain data to systematically identify SCNAs mediating gene dysregulation in cis. Using CESAM, we determined an estimate for the incidence of enhancer hijacking among the jumble of DNA rearrangements occurring in cancer genomes.” “Because we failed to reach a genomic inflation factor of


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