Multiple Mets Basal-like Breast Cancer Evolution

[PMID:27923045] [PLoS Medicine]

Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases

“multiclonal seeding from the primary tumor to the metastases can occur, indicating that metastatic cancers can originate from a collection of different subclones that together seed the metastatic site, rather than each metastasis forming from a single cell.” “the majority of functional mutations, those expressed and likely to be driving metastasis, are established in the primary tumor rather than being acquired during the spread of disease.”

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