Single-cell CNA in FFPE

[PMID:28165479] [Nature Medicine]

Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples

“Aspects germane to the success of this methodology were: (i) selection of FFPE samples based on objective assessment of DNA quality or size, (ii) the implementation of a variety of treatments to retrieve intact nuclei, and (iii) the introduction of a single-nucleus DNA repair step.”

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