LINSIGHT

[PMID:28288115] [Nature Genetics]

Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data

“substantially improves the prediction of noncoding nucleotide sites at which mutations are likely to have deleterious fitness consequences, and which, therefore, are likely to be phenotypically important. LINSIGHT combines a generalized linear model for functional genomic data with a probabilistic model of molecular evolution. The method is fast and highly scalable, enabling it to exploit the ‘big data’ available in modern genomics. “

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