SCcaller

[PMID:28319112] [Nature Methods]

Accurate identification of single-nucleotide variants in whole-genome-amplified single cells

“Mutation analysis in single-cell genomes is prone to artifacts associated with cell lysis and whole-genome amplification. Here we addressed these issues by developing single-cell multiple displacement amplification (SCMDA) and a general-purpose single-cell-variant caller, SCcaller”

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