Distinguishes Aneuploidy from Proliferation

[PMID:28320919] [Genome Research]

Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation

“Expression signatures have been widely used as markers for genomic instability, and bothsomatic copy number alterations (SCNAs) and point mutations (PMs) could be thought to associate with distinct signatures given their different formation mechanisms. Here we test this notion by systematically investigating SCNA, PM, and transcriptome data from 2660 cancer patients representing 11 tumor types.” “Gene sets related to cell growth and proliferation generally associated positively, and immunoregulatory gene sets negatively, with variant burden.” “Our results suggest that overexpression of cell-cycle–related genes are a characteristic of proliferation, and likely tumor evolution, rather than ongoing genomic instability.”


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s