Melanoma Subtypes

[PMID:28467829] [Nature]

Whole-genome landscapes of major melanoma subtypes

 

“Significantly mutated genes included BRAF, CDKN2A, NRAS and TP53 in cutaneous melanoma, BRAF, NRAS and NF1 in acral melanoma and SF3B1 in mucosal melanoma. Mutations affecting the TERT promoter were the most frequent of all; however, neither they nor ATRX mutations, which correlate with alternative telomere lengthening, were associated with greater telomere length.” “Telomere length was not correlated with melanoma subtype, chromothripsis or breakage–fusion–bridge events.”

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