Genomic Metrics and Immune Infiltration in TNBC

[PMID: 28750120] [JAMA Oncology]

Association Between Genomic Metrics and Immune Infiltration in Triple-Negative Breast Cancer

“calculate previously described immune metagene expression values and histologic lymphocyte counts to quantify immune infiltration and assign prognostic categories to TNBCs” “compared clonal heterogeneity, somatic total mutational load, neoantigen load, and somatic copy number alteration levels between immune-rich TNBC cohorts with good prognosis and immune-poor TNBC cohorts with poor prognosis.”

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