Bi-allelic Variants and HRD

[PMID: 29021619] [Nature Communications]

Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

“over 5% of all cancers harbor bi-allelic pathogenic mutations in HR-related genes” “bi-allelic alterations in HR DNA repair-related genes occur across cancer types, are mutually exclusive, and are associated with genomics features consistent with lack of competent HR DNA repair” mono-allelic alterations are not associated with HDR.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s